Effects of phenobarbital in cerebral ischemia. Part II: restitution of cerebral energy state, as well as of glycolytic metabolites, citric acid cycle intermediates and associated amino acids after pronounced incomplete ischemia.

نویسندگان

  • C H Nordström
  • S Rehncrona
  • B K Siesjö
چکیده

der Katze. Biochem Z 342: 518-531, 1965 50. Osburne R, Halsey JH: Cefebral blood flow as a predictor of recovery from ischemia in the gerbil. Arch Neurol 32:457-461, 1975 51. Marshall LF, Durity DJ, Lounsbury R et al: Experimental cerebral oligemia and ischemia produced by intracranial hypertension. Part 1: Pathophysiology, electroencephalography, cerebral blood flow, blood-brain barrier, and neurological function. J Neurosurg 43: 308-317, 1975 52. Mchedlishvili GI: Experimental model of controllable circulatory hypoxia (ischemia) of cerebral transferes. Neuropat Pol 11: 249-262, 1973 53. Smith AL, Wollman H: Cerebral blood flow and metabolism. Anesthesiology 36: 378-WO, 1972 54. Harp JR, Siesjo BK: Effects of anaesthesia on cerebral metabolism. In Gordon E (ed): A Basis and Practice of Neuroanaesthesia. Amsterdam, Excerpta Medica, p 47-82, 1975 55. Nilsson L: The influence of barbiturate anaesthesia upon the energy state and upon acid-base parameters of the brain in arterial hypotension and in asphyxia. Acta Neurol Scand 47: 233-253, 1971 56. Michenfelder JD, Theye RA: The influence of anaesthesia and ischemia on the cerebral energy state. In Whisnant JP (ed): Cerebral Vascular Diseases. New York, Grune and Stratton Inc., p 243-250, 1975 57. Maker HS, Lehrer GM: Effect of ischemia. In Lajtha, A (ed): Handbook of Neurochemistry, vol VI p 267-310. New York, Plenum Press, 1970 58. Lowry OH, Passonneau JV: The relationship between substrates and enzymes of glycolysis in brain. J Biol Chem 239: 1964

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Effects of phenobarbital in cerebral ischemia. Part I: cerebral energy metabolism during pronounced incomplete ischemia.

Changes in cerebral cortex concentrations of high-energy phosphates, glycolytic metabolites, citric acid cycle intermediates, associated amino acids, and ammonia, were studied after 5, 15 and 30 min of incomplete ischemia in rats anesthetized with 70% N2O or 150 mg.kg-1 of phenobartibal. Previous results have shown that with this type of ischemia (bilateral carotid artery occlusion combined wit...

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عنوان ژورنال:
  • Stroke

دوره 9 4  شماره 

صفحات  -

تاریخ انتشار 1978